Globally, the emergence of smart phones vitalized the ecosystem of mobile data service industry. Consequentially, mobile data traffic has been explosively growing and the speed of growth will be more steep. New spectrum will be required in order to properly accommodate the explosively growing mobile data traffic. However, it will be difficult to acquire a sufficient guard band between different frequency bands because the range of frequency which is suitable for wireless communications is limited. Thus, the performance degradation caused by inter-band interference will be one of challenging problems in the next generation mobile communication systems. In this paper, we analyze the performance degradation caused by inter-band interference by computer simulations in various environments. Our results show that the impact of the inter-band interference is more critical when own signal is poor or its own interference from neighboring cells is low.