This study aimed to compare the drinking behavior and health promoting lifestyle between Korean (n=304) and Japanese (n=244) female nursing students. The average score of health promoting lifestyle was statistically significant different after controlling covariables between the two countries. Spiritual growth of Korean was higher, while nutritional habits, interpersonal relationship and stress management of Japanese were higher. The frequency and amount of drinking, and the number of heavy drinkers of Korean were more than that of Japanese. The probability to be heavy drinkers in Korea was higher in interpersonal relationship and lower in spiritual growth, however the probability to be heavy drinkers in Japan was higher in health responsibility. Health educators need to provide nursing college students health education to improve healthy lifestyle including drinking behaviors.