In this study, we studied the effect of onion on hyperlipidemia in terms of factors, such as body weight, liver weight, kidney weight, heart weight, blood glucose, total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol. The hyperlipidemia supplement was significantly effective on the liver weight, kidney weight, blood glucose, total cholesterol, triglycerides, and LDL-cholesterol with the fixed effect model. However, the liver weight, blood glucose, total cholesterol, and triglycerides were significantly decreased with the random effect model on the heterogeneous factors selected by Galbraith plot. The existence of publication bias was checked by using a funnel plot.