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서지반출
Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies
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  • Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies
  • Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies
저자명
Wang. Xue-Jun,Zeng. Xian-Tao,Duan. Xiao-Li,Zeng. Huan-Chao,Shen. Rui,Zhou. Ping
간행물명
Asian Pacific journal of cancer prevention : APJCP
권/호정보
2012년|13권 7호|pp.3123-3127 (5 pages)
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아시아태평양암예방학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Objective: Experimental studies have suggested green tea to be a chemopreventive agent for colorectal cancer, and many studies have examined possible associations. However, the conclusions were inconsistent or even contradictory, so we performed a meta-analysis based on published case-control studies to explore if green tea is indeed a protective factor. Methods: PubMed was searched up to May $10^{th}$, 2012 for relevant studies, and references of included studies were manually searched. Finally 13 eligible studies, involving 12,636 cases and 38,419 controls were identified. After data extraction, a meta-analysis was performed using CMA v2 software. Results: The results indicated there may be a weak but not statistically significant reduced risk of colorectal cancer with high dose of green tea intake (OR=0.95, 95% CI:0.81-1.11, p=0.490.69-0.98). This protective effect was also found in all subgroups, except in American and European populations. Sensitivity analysis indicated the result to be robust. Publication bias was not detected by either funnel plot or Egger tests. Conclusion: The results of this meta-analysis indicate a weak lower tendency for colorectal cancer development with green tea consumption, but available epidemiologic data are insufficient to conclude that green tea may protect against colorectal cancer in humans.