Involved in a research for the application of seismic isolation to the nuclear industry, this study evaluates firstly the responses of seismic isolation system considering general ranges of structural period and damping ratio by using preliminary design formula. Secondly, coupling effects of input motions were evaluated to find out appropriate conditions of excitations and effect of the iteration for calculating yield displacement of lead core was also assessed in terms of response of a seismically isolated structure. Finally, the results of preliminary design calculation were compared with those of dynamic analysis and the propriety of the formula was evaluated and appropriate ranges of reduction factor were also suggested from the results.