Fatigue tests and analyses were carried out to investigate fatigue strength and crack initiation point of load-carrying asymmetric double bevel cruciform welded joints. Mesh-insensitive structural stress approach was adopted to estimate high precise fatigue life and crack initiation point. Two different case material and weld shape were considered in this study. Results of fatigue tests and analyses were compared and discussed in consideration of applicability of structural stress approach as the reliable fatigue assessment method of cruciform welded joints.