Worldwide cardiovascular diseases are the major cause of death. Aside from heart transplants, which are limited due to the availability of human donor hearts, artificial hearts are the only therapy available for terminal heart diseases. For various reasons, a total implantable artificial heart is desirable. But the limited space in the human thorax sets rigorous restrictions on the weight and dimensions of the device. Nevertheless, the appropriate functionality of the artificial heart must be ensured and blood damage must be prevented. These requirements set further restrictions to the drive of this device. In the this paper, two optimization methods, namely, the manual parameter variation and Differential Evolution algorithm, are presented and applied to match the specifications of an artificial heart.