The NASA Antarctica balloon experiment CREAM has successfully collected the data of energetic cosmic rays during six flights in past years. It recently observed the unexpected discrete hardening in energy spectra of comic rays. However high-statistics data of energetic cosmic rays are required for the further investigation of the unexpected hardening in comic-ray energy spectra. The International Space Station (ISS) is an ideal platform for the CREAM experiment to investigate the unexpected hardening and explore the fundamental issues like the acceleration mechanism and the origin of energetic cosmic rays because of the high duty cycle of the experiment in the ISS platform. We will present the design of the ISS-CREAM experiment, and the development and fabrication status of the detector components including the 4-layer silicon charge detector which will measure the charge constitution of cosmic rays with unprecedented accuracy.