Objectives : The purpose of this study was to identify the effects of self-acupressure on the visual health of college students. Methods : A nonequivalent control group pretest-posttest design was used. Participants were determined by OSDI(ocular surface disease index) and the Schirmer test, they were assigned to an experimental group of 22 and control group of 22. The experimental group participated in self-acupressure, which were practiced 2 times a day, 5 days a week for 4 weeks. Results : Scores of ocular surface disease index, Schirmer test and ocular fatigue were significantly better in the experimental group after the intervention compared to the control group. Conclusions : The result indicate that self-acupressure is an effective nursing intervention for improving the dry eye syndrome and decreasing ocular fatigue in college students.