Objectives : The objective of this case report was to observe the effect of musculoskeletal ultrasound-guided acupotomy therapy on common peroneal nerve palsy. Methods : From June, 2010 to September, 2012, 3 patients clinically diagnosed as common peroneal nerve palsy were treated with general oriental medicine therapy (acupuncture, pharmacopuncture, moxibustion, cupping, physical therapy, herbal medication) and acupotomy. Results : The foot drop of the patients was remarkably improved. Conclusions : This study demonstrates that oriental medical treatment with acuputomy therapy hasnotable effect in improving symptoms of common peroneal nerve palsy. As though we had not widly experienced in this treatment, more research is needed.