Purpose: The purpose of this study was to examine the effects of the systematic breathing exercise program on recovery of patients with pneumothorax. Methods: An nonequivalent interrupted time-series control group posttest design was used. Participants were 40 inpatients (Experimental Group; 20, Control Group; 20) at the one University Hospital in U city. The systematic breathing exercise program including education on deep breathing exercise using incentive spirometry, Range of motion (ROM) exercise in shoulder joint, walking exercise and feedback were provided to the experimental group, while the control group carried out deep breathing exercise using incentive spirometry. The duration of chest tube insertion, duration of hospitalization, and frequency of analgesics use were measured. The data were analysed by a SPSS/WIN program. Results: The duration of chest tube insertion and duration of hospitalization in the experimental group were significantly shorter than the control group. However, there is no difference of the frequency of analgesics use between the experimental group and control group. Conclusion: The result showed that the systematic breathing exercise program was effective to improve recovery of patients with pneumothorax. This program can be applied in hospitals for patients with pneumothorax as one of the nursing intervention modalities.