In setting an experimental design for the prediction outside the experimental region (extrapolation design), it is natural for the experimenter to be very careful about the validity of the model for the design because the experimenter is not certain whether the model can be extended beyond the design region or not. In this paper, a hybrid constrained type approach was adopted in dealing model uncertainty as well as the prediction error using the three basic principles available in literature, maxi-min, constrained, and compound design. Furthermore, the effect of the distance of the extrapolation design point from the design region is investigated. A search algorithm was used because the classical exchange algorithm was found to be complex due to the characteristic of the problem.