Purpose: The purpose of this study was to study the job satisfaction and influential factors of clinical nurses. Methods: Data were collected using questionaires from 323 nurses who were working at hospitals located in M city. For data analysis, t-test, ANOVA, Duncan test, Pearson correlation coefficient and multiple regression were used. Results: The means of self-esteem, organizational commitment, and job satisfaction were 3.01, 3.23, and 3.04, respectively. There were statistically significant correlations among self-esteem, organizational commitment, and job satisfaction. Significant predictors of job satisfaction were organizational commitment and education opportunity. These two factors accounted for 50.9% of variance in job satisfaction of the nurses. Organizational commitment was the most influential variable. Conclusion: In rapidly changing environments, hospital system has been transformed into a highly complex and specialized structure. To manage human resources and reduce turnover rates, it is necessary to develop a strategy for nurses to improve the levels of self-esteem, organizational commitment, and job satisfaction.