This article describes the development, evaluation and dissemination of biological nursing (bionursing) science courses established in Korea. Prior to this innovation the subject such as anatomy, physiology, biochemistry, microbiology, pharmacology and pathology were taught by non-nursing faculties, such as basic medical science faculty members. And it often did not meet and satisfy the needs of most undergraduate nursing students. To meet these needs, we have developed four bionursing courses by overhauling individual courses and integrating these by creating new titles, objectives, and contents. In this process, the Korean Society of Biological Nursing has made enormous efforts to standardize the contents of the courses and to develop standard syllabus of four bionursing subjects. This article also suggests for further development of bionursing science such as enhanced linkage of the contents of bionursing science courses with clinical practice, reinforcement of teaching competency of professors, and activation of researches using various biological measurement to provide concrete evidences for nursing practice.