This paper presents a numerical study on the performance improvement of axial-flow pump with guide vanes. Design optimization for guide vanes in an axial-flow pump has been studied through the implementation of a commercial CFD code and DOE (design of experiments). We also discussed how to improve the performance of the axial-flow pump by designing the guide vanes. Geometric design variables were defined by the meridional plane and vane plane development of guide vanes. The effect of hub tip ratio analyzed the meridional plane of guide vanes. The importance of the geometric design variables was analyzed using $2^k$ factorial designs. The objective functions for guide vane geometric variables were defined as the total efficiency and the total head at the design flow rate. From the $2^k$ factorial design results, the important design variables were found and the performance was increased in comparison with the base design model.