Sound packages and damping materials have been widely applied on the floor to decrease the interior noise of a vehicle. Based on the previous researches on the low-noise vehicles, weight optimization through minimization of damping material usage is required while decreasing mid and high frequency range noise by application of sound packages. This paper describes the analysis process of robust design of vehicle body structure before applying damping materials and focuses on the analysis and test process of the location optimization at the stage of damping material application. A vibration experiment for the analysis of floor panel velocity with respect to the excitation of suspension attachment parts at the underfloor of a vehicle is performed. And through the improvement correlation between FEA and TEST, a design guide to optimize damping materials application in the early design stage is proposed. A research on vibration damping steel sheets and liquid acoustic spray on deadener(LASD) is performed to minimize manufacturing time and to minimize the space for pre-existing asphalt damping materials. As results of this study, panel stiffness is achieved through curved surface panel and bead optimization. And test baseline of optimum design is suggested through damping material optimization. And finally, through re-establishing the analysis process for vibration reduction of vehicle floors and lightweight design of damping materials, it is possible to design damping materials efficiently in the preceding stage of design.