This paper is concerned with the development of power amplifier and controller for piezoelectric actuator and sensor used in smart structures. Even though a high-voltage power amplifier is provided in the form of an operational amplifier, a very high DC voltage is still necessary as a power supply. In this study, we propose a low-cost design for the power amplifier including the DC power supply. We also need a controller on which a control algorithm will be mounted. In general, a digital signal processing chip is popularly used because of high speed. However, only commercial product is available for smart structure applications. In this paper, a controller consisting of a DSP and electronic circuits suitable for piezoelectric sensor and actuator pair is proposed. To validate the proposed controller with power amplifier, experiment on smart structure was carried out. The experimental results show that the proposed control system can be effectively used for smart structure applications with low cost.