When a vehicle passes through turnout, it is required to minimize the changes of lateral force for running safety of vehicle. Therefore, it is necessary to analyze interaction between the vehicle and the turnout in order to estimate the lateral force and the derailment coefficient on the turnout. In this paper, analysis model of the vehicle and turnout are established and analysis is carried out when the vehicle passes through turnout in order to improve running safety of the vehicle on turnout. To verify the vehicle and turnout analysis model, the contact points between wheel and rail and the influence of changing cradle and tongue rail are also discussed.