High-Performance Concrete (HPC) as a promising construction material has been widely used in infrastructures and high-rise buildings etc. However, its high autogenous shrinkage especially in its early age becomes one of the key problems endangering long-term durability of HPC structures. This paper reports the study of early age autogenous shrinkage of large scaled HPC column specimens by embedded Fiber Bragg-Grating (FBG) strain sensor. Temperature compensation for FBG strain sensor by thermocouple was also attempted in this paper, and the results were reasonable and acceptable comparing with the result compensated by FBG temperature sensor. Reinforcement influence, size effect and temperature effect on HPC autogenous shrinkage were also analyzed respectively in this paper.