- 백단향추출물의 항산화, 항혈소판 응집 및 혈전 용해능에 관한 연구
- ㆍ 저자명
- 송영위,이지현,송규주,구병수,김근우,Sung. Yung-Wei,Lee. Ji-Hyun,Song. Kyoo-Ju,Koo. Byung-Soo,Kim. Geun-Woo
- ㆍ 간행물명
- 동의신경정신과학회지
- ㆍ 권/호정보
- 2012년|23권 1호|pp.115-128 (14 pages)
- ㆍ 발행정보
- 대한한방신경정신과학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Objectives : To evaluate the in vitro scavenging activity, inhibitory effect of LDL oxidation of pro-oxidant reactive species, anti-platelet aggregative effects and anti-thrombosis effects in response to treatment with SA using various screening methods including biological and non-biological oxidants. Methods : The antioxidant activity concerning extract from SA was studied with in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on $Cu^{2+}$-induced human LDL oxidation and the inhibitory effect on thrombin-induced platelet aggregation and thrombosis. Results : SA extracts were found to have a potent scavenging activity regarding oxidative stress as well as an inhibitory effect towards LDL oxidation, platelet aggregation, and thrombosis. Conclusions : The SA extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis.