When a high-speed train passes an underground station, large pressure waves are generated due to the piston effect. These pressure waves can cause the problems of vibration and noise as well as the ear discomfort of passengers at the underground station. This work numerically analyzed the pressure wave generation and propagation in an high-speed railway underground station, and the optimal location for vent shafts was studied to improve the passenger comfort by reducing the magnitude of the pressure wave and its rate of change. The evolution of pressure field in the underground station was calculated using a CFD(Computational Fluid Dynamics) software(Fluent), where the axis-symmetric two-dimensional model verified by Wu was used. And this study is applied to modelling of the underground station and the tunnel from Daegok station A-line of GTX(Great Train Express). From the result, we can have a conclusion that the role of vent shafts respectively were different according to the position in and out the underground station. Also Vent shaft in the underground station widely reduced pressure magnitude. And vent shaft out underground station reduced initial pressure peak value. Double vent shafts installed at tunnel toward station entrance and inside of the tunnel are the most efficient to reduce pressure. and pressure reduction increases according to the number of vent shaft.