During maxillofacial surgery, the infraorbital and mental nerves are blocked at eac foramen to induce local anesthesia. This study examined the relative locations of the infraorbital foramen (IOF) and mental foramen (MF) based on softtissue landmarks. Twenty-eight hemifacial cadavers were dissected to expose the IOF and MF. The distances between the bilateral IOFs, the bilateral MFs, the alae of the nose (alares), and the corners of the mouth (cheilions) were measured directly on cadavers by using a digital vernier caliper. The vertical and horizontal distances of the IOF and MF relative to the alare and cheilion were measured indirectly on digital photographs using Adobe Photoshop (Adobe, CA, USA). The distance between the bilateral IOFs ($58.09{pm}4.04mm$) was longer than the distance between the bilateral MFs ($50.32{pm}1.93mm$). The distances between the bilateral alares and cheilions were $41.22{pm}3.44mm$ and $58.43{pm}6.62mm$, respectively. The IOF was located $12.92{pm}3.75mm$ superior and $7.88{pm}2.56mm$ lateral to the alare, and the vertical angle (Angle 1) between these structures was $31.67{pm}13.36^{circ}$ superolaterally. The MF was located $21.83{pm}3.26mm$ inferior and $5.56{pm}3.37mm$ medial to the cheilion, and the vertical angle (Angle 2) between these structures was $14.05{pm}10.12^{circ}$ inferomedially. In conclusion, these results provide more detailed information about the locations of the IOF and MF relative to soft-tissue landmarks.