DNV-OS-F101 includes the concept development, design, construction, operation,and abandonment of offshore pipeline systems. The main objective of this offshore standard (OS) is to ensure that pipeline systems are safe during the installation and operational period. The pipeline design philosophy also includes public safety and environmental protection. The mechanical wall thickness design of a pipeline shall follow the design objectives and safety philosophy. This new design code includes a very sophisticated design procedure to ensure a safe pipeline, public safety, and environmental protection. This paper presents the results of a parametric study for the wall thickness design of offshore pipelines. A design matrix was developed to cover the many design factors of pipeline integrity, public safety, and environmental protection. Sensitivity analyses of the various parameters were carried out to identify the impacts on offshore pipeline design.