A reinforced concrete (RC) framed structure detailed according to non-seismic detailing provisions as per Indian Standard was tested on shake table under dynamic loads. The structure had 3 main storeys and an additional storey to simulate the footing to plinth level. In plan the structure was symmetric with 2 bays in each direction. In order to optimize the information obtained from the tests, tests were planned in three different stages. In the first stage, tests were done with masonry infill panels in one direction to obtain information on the stiffness increase due to addition of infill panels. In second stage, the infills were removed and tests were conducted on the structure without and with tuned liquid dampers (TLD) on the roof of the structure to investigate the effect of TLD on seismic response of the structure. In the third stage, tests were conducted on bare frame structure under biaxial time histories with gradually increasing peak ground acceleration (PGA) till failure. The simulated earthquakes represented low, moderate and severe seismic ground motions. The effects of masonry infill panels on dynamic characteristics of the structure, effectiveness of TLD in reducing the seismic response of structure and the failure patterns of non-seismically detailed structures, are clearly brought out. Details of design and similitude are also discussed.