Fuzzy logic based control has recently been proposed for regulating the properties of magnetorheological (MR) dampers in an effort to reduce vibrations of structures subjected to seismic excitations. So far, most studies showing the effectiveness of these algorithms have focused on the use of a single MR damper. Because multiple dampers would be needed in practical applications, this study aims to evaluate the effects of multiple individually tuned fuzzy-controlled MR dampers in reducing responses of a multi-degree-of-freedom structure subjected to seismic motions. Two different fuzzy-control algorithms are considered, a traditional controller where all parameters are kept constant, and a gain-scheduling control strategy. Different damper placement configurations are also considered, as are different numbers of MR dampers. To determine the robustness of the fuzzy controllers developed to changes in ground excitation, the structure selected is subjected to different earthquake records. Responses analyzed include peak and root mean square displacements, accelerations, and interstory drifts. Results obtained with the fuzzy-based control schemes are compared to passive control strategies.