This study explores a coefficient-based seismic capacity assessment method with a special emphasis on low-rise masonry in-filled (MI) reinforced concrete (RC) buildings subjected to earthquake motion. The coefficient-based method without requiring any complicated finite element analysis is a simplified procedure to assess the maximum spectral acceleration capacity of buildings. This paper first compares the fundamental periods of MI RC structures obtained, respectively, from experimental period data and empirical period-height formulas. The coefficient-based method for low-rise masonry buildings is then calibrated by the published experimental results obtained from shaking table tests. The comparison of the experimental and estimated results indicates that the simplified coefficient-based method can provide good approximations of the maximum spectral accelerations at peak loads of the low-rise masonry reinforced concrete buildings if a proper set of drift factors and initial fundamental vibration periods of structures are used.