The building frame and its foundation along with the soil on which it rests, together constitute a complete structural system. In the conventional analysis, a structure is analysed as an independent frame assuming unyielding supports and the interactive response of soil-foundation is disregarded. This kind of analysis does not provide realistic behaviour and sometimes may cause failure of the structure. Also, the conventional analysis considers infill wall as non-structural elements and ignores its interaction with the bounding frame. In fact, the infill wall provides lateral stiffness and thus plays vital role in resisting the seismic forces. Thus, it is essential to consider its effect especially in case of high rise buildings. In the present research work the building frame, infill wall, isolated column footings (open foundation) and soil mass are considered to act as a single integral compatible structural unit to predict the nonlinear interaction behaviour of the composite system under seismic forces. The coupled isoparametric finite-infinite elements have been used for modelling of the interaction system. The material of the frame, infill and column footings has been assumed to follow perfectly linear elastic relationship whereas the well known hyperbolic soil model is used to account for the nonlinearity of the soil mass.