The proposed research includes a comprehensive study on the seismic vulnerability assessment of typical building types, representative of the structural materials, the seismic codes and the construction techniques of Southern Europe. A damage database is created after the elaboration of the results of the observational data obtained from post-earthquake surveys carried out in the area struck by the September 7, 1999 Athens earthquake, a near field seismic event in an extended urban region. The observational database comprises 180.945 buildings which developed damage of varying degree, type and extent. The dataset is elaborated in order to gather useful information about the structural parameters influence on the seismic vulnerability and their correlation to the type and degree of building damages in near field earthquakes. The damage calibration of the observational data was based on label - damage provided by Earthquake Planning and Protection Organization (EPPO) in Greece and referred to the qualitative characterization for the recording of damage in post-earthquake surveys. Important conclusions are drawn on the parameters that influence the seismic response based on the wide homogeneous database which adds to the reliability of the collected information and reduces the scatter on the produced results.