Ground motion scaling techniques are actively debated in the earthquake engineering community. Considerations such as what amplitude, over what period range and to what target spectrum are amongst the questions of practical importance. In this paper, the effect of various ground motion scaling approaches are explored using three reinforced concrete prototypical building models of 8, 12 and 20 stories designed to respond nonlinearly under a design level earthquake event in the seismically active Southern California region. Twenty-one recorded earthquake motions are selected using a probabilistic seismic hazard analysis and subsequently scaled using four different strategies. These motions are subsequently compared to spectrally compatible motions. The nonlinear response of a planar frameidealized building is evaluated in terms of plasticity distribution, floor level acceleration and uncorrelated acceleration amplification ratio distributions; and interstory drift distributions. The most pronounced response variability observed in association with the scaling method is the extent of higher mode participation in the nonlinear demands.