In this study, performance of HFC32/HFC152a mixture is measured in the composition range of 20 to 50% R32 with an interval of 10% for the comparison with the conventional HCFC22 in water-source heat pumps. Tests are carried out under the same capacity in a heat pump bench tester equipped with a variable speed compressor at the evaporation and condensation temperatures of 7/$45^{circ}C$ and -7/$41^{circ}C$ for summer and winter conditions, respectively. Test results show that the compressor power of the HFC32/HFC152a mixture is 13.7% lower than that of HCFC22 while the coefficient of performance(COP) the HFC32/HFC152a mixture is 15.8% higher than that of HCFC22. Hence, from the view point of energy efficiency, the HFC32/HFC152a mixture is excellent as compared to HCFC22. Compressor discharge temperatures of HFC32/HFC152a mixture are increased up to $15.4^{circ}C$ as compared to that of HCFC22. The amount of charge for HFC32/HFC152 mixture decrease up to 27% as compared to that of HCFC22. Overall, HFC32/ HFC152a mixture is an excellent long term candidate to replace HCFC22 in water-source heat pumps.