Wireless Fidelity (WiFi) and Wireless microphone are assumed to operate on adjacent channels in TV White Spaces(TVWS). The Scenario of WiFi potentially interfering with Wireless microphone is analyzed through Minimum Coupling Loss (MCL) and Spectrum Engineering Advanced Monte Carlo Analysis Tool (SEAMCAT) based on the Monte-Carlo simulation method. In the case of single WiFi interfering with Wireless microphone, the protection distance between WiFi and the Wireless microphone should be at least 25.12 m to avoid WiFi impact on Wireless microphone. When the active number of WiFi is 12, the guard band between WiFi and Wireless microphone should not be less than 4.97 MHz to guarantee that WiFi does not interfere with the Wireless microphone.