The purpose of the present objective is to elucidate the folklore use of the plant, Mirabilis jalapa and Mirabilis japonica as potential anti-inflammatory and antinociceptive. This present study is emphasised on the combined effect of the hydroalcoholic leaf extract as antiinflammatory and antinociceptive. Hydroalcoholic extract of the leaves was prepared by repetitive maceration. The anti-inflammatory activity was evaluated by using carrageenan induced paw edema models in Wistar albino rats while the antinociceptive effect was evaluated using acetic acid induced writhing model and Tail immersion method in Swiss albino mice. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The extract has shown significant (P<0.05) inhibition of paw oedema, 23.384 and 34.923 on 3rd hour at the doses of 100 and 200 mg/kg, respectively. Similarly animal model for antinociceptive activity i.e. acetic acid induced writhing and Tail immersion produced significant analgesic activity. In acetic acid induced writhing and tail immersion the extract at 20, 50 and 70 mg/kg (P<0.001) showed significant activity. The results of present study demonstrate that hydroalcoholic extract of the leaves possess significant (P<0.05) anti-inflammatory potential and (P<0.001) antinociceptive activity.