A numerical investigation has been performed to identify the rarefaction effects on the flow structure of an isolated micron-sized spherical particle. An isothermal sphere in the slip flow regime $10^{-3}{leq}Kn{leq}10^{-1}$ at intermediate Reynolds numbers ($1{leq}Re{leq}50$) is considered. The Navier-Stokes equations are solved by a control volume technique in conjunction with the velocity slip boundary condition. It was found that the wake region can shrink considerably as the Knudsen number increases. Furthermore, the skin friction and pressure drag coefficients decrease as the Knudsen number increases due to the reduction in normal velocity gradients and shrinkage of the wake region, respectively. Engineering correlations for predicting the total drag coefficient in the slip flow regime are presented.