The present article aims to report the effects of hydrodynamic slip on entropy generation in the boundary layer flow over a vertical surface with convective boundary condition. Suitable similarity transformations are used to transform the fundamental equations of hydrodynamic and thermal boundary layer flow into ordinary differential equations. The governing equations are then solved numerically using the shooting method and the velocity and the temperature profiles are obtained for various values of parameters involved in the governing equations. The expressions for the entropy generation number and the Bejan number are presented and the results are discussed graphically and quantitatively for the slip parameter, the local Grashof number, the Prandtl number, the local convective heat transfer parameter, the group parameter and the local Reynolds number. It is observed that due to the presence of slip, entropy production in a thermal system can be controlled and reduced.