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Antibody Response in Korean Raccoon Dogs Inoculated with Inactivated Rabies Vaccines
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  • Antibody Response in Korean Raccoon Dogs Inoculated with Inactivated Rabies Vaccines
  • Antibody Response in Korean Raccoon Dogs Inoculated with Inactivated Rabies Vaccines
저자명
Yang. Dong-Kun,Go. Tae-Oh,Nam. Young-Hee,Kim. Ha-Hyun,Cho. Soo-Dong,Lee. Kyung-Woo,Choi. Sung-Suk,Song. Jae-Young
간행물명
Journal of bacteriology and virology : JBV
권/호정보
2012년|42권 3호|pp.242-246 (5 pages)
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대한미생물학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Since sylvatic rabies was first identified in South Korea in 1993, over three million bait vaccine doses have been distributed to rabies risk regions in order to block transmission of rabies among wild animals. New progressive strategy is needed to eliminate sylvatic rabies completely in rabies risk regions. Before applying the preventive program related to eradication, immunogenicity of inactivated rabies vaccines available in Korea has to be evaluated in Korean raccoon dogs (Nyctereutes procyonoides koreensis). Six groups of raccoon dogs in wild rescue center of Gyeonggi-do were vaccinated intramuscularly with single dose of six inactivated commercial rabies vaccines (designated A to F). Serum samples at the time of vaccination, and two and four weeks post vaccination were obtained and analyzed by virus neutralizing assay (VNA). All raccoon dogs inoculated with vaccines C, D, E or F, showed VN antibody titers ranging from 0.5 to 13.77 IU/ml. Half of four raccoon dogs immunized with vaccine B revealed VN titer over 0.5 IU/ml, and one of four raccoon dogs inoculated with vaccine A showed protective antibody titer. This finding suggests that most of the commercially available inactivated rabies vaccines could induce protective immunity in Korean raccoon dogs and be applicable to new rabies control program.