In this paper, geometrically non-linear post-buckling analyses were performed to study the effect of sheet thickness, deployment angle, and load ratio on the crease-wrinkle interaction. A square sheet configuration with a single transverse crease was modeled using thin shell elements. The analysis proceeded by initially providing a realistic deployed state of a creased membrane sheet. Then an uneven corner loading was applied to introduce wrinkling. The effects of the induced anisotropy from the crease on the fine-scale detail of the wrinkle evolution, as a function of sheet thickness, loading, and crease deployment angle were systematically investigated. Significant differences were found in sheet compliance and crease-wrinkle interaction as these parameters were varied.