A multi-modal sensing M2M healthcare monitoring system for the continuous monitoring of patients under their natural physiological states or elderly persons with chronic diseases is summarized. The system is designed for homecare or the monitoring of the elderly who live in country side or small rest home without enough support from caregivers or doctors, instead of patient monitoring in big hospital environment. Further insights into the natural cause and progression of diseases are afforded by context-aware sensing, which includes the use of accelerometers to monitor patient activities, or by location-aware indoor tracking based on ultrasonic and RF sensing. Moreover, indoor location tracking provides information about the location of patients in their physical environment and helps the caregiver in the provision of appropriate support.