In terms of injection processing parameters, a mathematical model for prediction of warpage was formulated based on design of experiments (DOE). First, the five most influential parameters were screened by using fractional factorial design (FFD): melt temperature, coolant temperature, injection time, V/P switch over and mold temperature. Second, considering the other four principal processing parameters except the melt temperature, the predicting mathematical model was founded by using central composite design (CCD) of experiments and FE simulation. Finally, the results of statistical analysis were collected from software Moldflow. The results suggested that the mathematical model can be used to predict warpage with adequate accuracy. Hence, it indicated that corrective and iterative design steps can be initiated and implemented for better quality of products without resorting to physical trials in plastics injection mold by using this predicting mathematical model.