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서지반출
N-Nitrosodimethylamine in the Kashmiri Diet and Possible Roles in the High Incidence of Gastrointestinal Cancers
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  • N-Nitrosodimethylamine in the Kashmiri Diet and Possible Roles in the High Incidence of Gastrointestinal Cancers
  • N-Nitrosodimethylamine in the Kashmiri Diet and Possible Roles in the High Incidence of Gastrointestinal Cancers
저자명
Chikan. Naveed A.,Shabir. Nadeem,Shaffi. Sheikh,Mir. Manzoor R.,Patel. Trupti N.
간행물명
Asian Pacific journal of cancer prevention : APJCP
권/호정보
2012년|13권 3호|pp.1077-1079 (3 pages)
발행정보
아시아태평양암예방학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The Kashmiri population is culturally distinct with special dietary features owing to the temperate climatic conditions of Kashmir valley. This has habituated the population to preserve food in smoked, pickled and sundried forms which include considerable amounts of $N$-nitroso compounds (NOCs). These are known to cause cytotoxicity, DNA damage, mutation, unscheduled DNA synthesis and DNA methylation. All of these changes at molecular level are known to contribute to the pathogenesis of cancer. One of the prominent NOCs found in Kashmiri food is $N$-Nitrosodimethylamine (NDMA). Here we review the occurrence of NDMA in sundried foods, dried fish, kehwa, traditional pickle, $Brassica$ $oleracia$ and $tobbaco$. We also discuss its possible role in the high prevalence of gastrointestinal cancers in Kashmir.