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Effect of Feeding Time Shift on the Reproductive System in Male Rats
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  • Effect of Feeding Time Shift on the Reproductive System in Male Rats
  • Effect of Feeding Time Shift on the Reproductive System in Male Rats
저자명
Kwak. Byung-Kook,Lee. Sung-Ho
간행물명
발생과 생식
권/호정보
2012년|16권 1호|pp.53-58 (6 pages)
발행정보
한국발생생물학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Circadian rhythmicity (e.g. secretory pattern of hormones) plays an important role in the control of reproductive function. We hypothesized that the alteration of feeding pattern via meal time shift/restriction might disrupt circadian rhythms in energy balance, and induce changes in reproductive activities. To test this hypothesis, we employed simple animal model that not allowing $ad$ $libitum$ feeding but daytime only feeding. The animals of $ad$ $libitum$ feeding group (Control) have free access to food for 4 weeks. The day feeding (=reverse feeding, RF) animals (RF group) have restricted access to food during daytime (0900-1800) for 4 weeks. After completing the feeding schedules, body weights, testis and epididymis weights of animals from both group were not significantly different. However, the weights of seminal vesicle (control : RF group = $0.233{pm}0.014g$ : $0.188{pm}0.009g$, $p$<0.01) and prostate (control : RF group = $0.358{pm}0.015g$ : $0.259{pm}0.015g$, $p$<0.001) were significantly lower in RF group animals. The mRNA levels of pituitary common alpha subunit ($C{alpha}$; control : RF group = $1.0{pm}0.0699$ AU : $0.1923{pm}0.0270$ AU, $p$<0.001) and $FSH{eta}$ (control : RF group = $1.0{pm}0.1489$ AU : $0.5237{pm}0.1088$ AU, $p$<0.05) were significantly decreased in RF group. The mRNA levels of ACTH were not significantly different. We were unable to find any prominent difference in the microstructures of epididymis, and there were slight alterations in those of seminal vesicles after 4 weeks of reversed feeding when compared to control samples. The present study demonstrates that the shift and/or restriction of feeding time could alter the pituitary gonadotropin expression and the weights of seminal vesicle and prostate in rats. These data suggest the lowered gonadotropin inputs may decrease androgen secretion form testis, and consequently results in poor response of androgen-dependent tissues such as seminal vesicle and prostate.