Antimicrobial resistance in bacteria is problematic in clinical settings and is a growing threat to public health. Multidrug-resistant and pandrug-resistant non-fermenters such as $Acinetobacter$ spp. and $Pseudomonas$ $aeruginosa$ have recently emerged as a great concern worldwide. Particularly, the prevalence of carbapenem resistance in $Acinetobacter$ spp. and $P.$ $aeruginosa$ is problematic, and emergence of polymyxin resistance is ominous. In this review, we discuss carbapenem and polymyxin resistance in $Acinetobacter$ spp. and $P.$ $aeruginosa$ isolates and their major clones.