Design, Synthesis, and Anti-influenza Viral Activities of 1,3-Diarylprop-2-en-1-ones: A Novel Class of Neuraminidase Inhibitors

Design, Synthesis, and Anti-influenza Viral Activities of 1,3-Diarylprop-2-en-1-ones: A Novel Class of Neuraminidase Inhibitors
Design, Synthesis, and Anti-influenza Viral Activities of 1,3-Diarylprop-2-en-1-ones: A Novel Class of Neuraminidase Inhibitors

ㆍ 저자명: Kinger. Mayank,Park. Yong Dae,Park. Jeong Hoon,Hur. Min Goo,Jeong. Hyung Jae,Park. Su-Jin,Lee. Woo Song,Kim. Sang Wook,Yang. Seu
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2012년|35권 4호|pp.633-638 (6 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an $IC_{50}$ value of 1.5 ${mu}M$.

키워드

Anti-influenza activity Synthesis Neuraminidase 1 3-Diarylprop-2-en-1-ones

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