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GLOBAL STABILITY OF HIV INFECTION MODELS WITH INTRACELLULAR DELAYS
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  • GLOBAL STABILITY OF HIV INFECTION MODELS WITH INTRACELLULAR DELAYS
  • GLOBAL STABILITY OF HIV INFECTION MODELS WITH INTRACELLULAR DELAYS
저자명
Elaiw. Ahmed,Hassanien. Ismail,Azoz. Shimaa
간행물명
Journal of the Korean Mathematical Society
권/호정보
2012년|49권 4호|pp.779-794 (16 pages)
발행정보
대한수학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In this paper, we study the global stability of two mathematical models for human immunodeficiency virus (HIV) infection with intra-cellular delays. The first model is a 5-dimensional nonlinear delay ODEs that describes the interaction of the HIV with two classes of target cells, $CD4^+$ T cells and macrophages taking into account the saturation infection rate. The second model generalizes the first one by assuming that the infection rate is given by Beddington-DeAngelis functional response. Two time delays are used to describe the time periods between viral entry the two classes of target cells and the production of new virus particles. Lyapunov functionals are constructed and LaSalle-type theorem for delay differential equation is used to establish the global asymptotic stability of the uninfected and infected steady states of the HIV infection models. We have proven that if the basic reproduction number $R_0$ is less than unity, then the uninfected steady state is globally asymptotically stable, and if the infected steady state exists, then it is globally asymptotically stable for all time delays.