Air traffic controllers often experience fatigue and stress on the job due to work-related factors. Performance impairment resulting from fatigue and stress is an important concern for aviation safety. The goal of this research was to investigate fatigue and stress factors for air traffic controllers. The research involved an extensive literature review of fatigue and stress in the air traffic control environment and surveyed fatigue and job stress level of Korean air traffic controllers compared to other occupation groups. Results of survey showed that fatigue and stress levels of air traffic controllers were significantly higher than other occupation groups. Specially air traffic controllers reported that night work created high level of fatigue and perceived that physical environment and job demand induced high level of stress. In addition, implications for fatigue and stress management were discussed.