Recently, as the importance of the interior noise in a ship cabin has risen, ship builders have becomeconcerned about the use of noise reduction panels to reduce cabin noise. The results of previous researches have been based on analytical and experimental methods using simple sandwich panels. However, panel structures are becoming more complex to improve the transmission loss. Thus, researches that analyze the transmission loss of a panel are reaching the limit of study. This paper reports on research that was performed to determine the sound transmission characteristics of multi-complex panels applicable to high value-added vessels. It presents comparisons between analytical methods and experimental results by using a mini-reverberant chamber with components of sound attenuation panels, including the core and surface materials. The sound transmission loss of multi-complex panels are also analyzed in terms of the influences of the inside perforate plates and air gap thickness on the attenuation. Finally, the multi-complex panel with the highest noise attenuation is proposed based on the analysis results and experimental results in mini-reverberant chamber, which wereverified using a real-size reverberant chamber.