With the foot-and-mouth disease problems emerging as a serious social issue, this study set out to analyze the problems with the current setting of preventive zones against epidemics and find ways to minimize damage through preventive measures. For those purposes, the study analyzed the outbreaks of the foot-and-mouth disease and assumed that the disease would be transmitted via vehicles along the roads based on the network map of national roads and boundaries among administrative districts to conduct network analysis. The analysis results were then used to estimate spread time, whose results were then categorized according to lineal road distance and actual road distance. Then lineal moving speed and actual moving speed on the road were obtained according to the national roads and administrative districts to analyze the problems with the current method of setting preventive zones against the foot-and-mouth disease. As for spread speed around the areas where the foot-and-mouth disease broke out, the average lineal spread speed was 53.9km/day, and the average spread speed on the road was 71.1km/day, which indicates there are problems with the current method of setting preventive zones against epidemics.