Objectives: Effective and efficient response for public health crisis necessitate planning how to respond and mobilize the resources in schools. We preformed this study to develop the strategies to improve efficiency of school health education in an outbreak of pandemic disease. Methods: We tried to review the policies, regulations and response systems of all related sectors, and advanced cases associated with pandemic disease control measures by searching databases and on-line networks connected with the Korean Ministry of Education, Science and Technology. Results: It was important to implement a consistent and systematic approach for educational offices and schools to prevent confusion resulted from the inaccurate information. First, the systems and action plans for school health should be established to prepare and respond to an outbreak of pandemic disease. Secondly, the strategies to improve the efficiency of school health education in public health crisis should be in place. Finally, the personnel pool would be needed to provide the crisis management programs. Conclusion: In order for staffs and students to have abilities to respond in an outbreak of pandemic disease, comprehensive school health approaches and efficient educational efforts should be prepared in collaboration with related sectors.