Purpose: The purpose of this study was to examine the effect of an individual education program on breast cancer patients who received chemotherapy. Methods: The quasi-experimental design was employed with a nonequivalent control group pre-post test. The study was performed from January 1 to July 30, 2010 for the patients who were firstly treated by A C (Adriamycin, Cyclophosphamide) chemotherapy in a university hospital. Control group was recruited first to prevent treatment diffusion. The experimental group was recruited and received an individual education during 30 minutes. The collected data were analyzed using SPSS 16.0 version. ${chi}^2$-test, t-test, and the Pearson correlation were implemented in order to examine the effect of the individual education among the patients who are treated by chemotherapy. Results: The experimental group had a greater improvement in self-care knowledge (t=-5.236, p=.001), and self-care performance (t=-6.543, p=.004) than did control group. Moreover, the experimental group had significantly positive correlation between self-care knowledge and self-care performance (r=.494, p=.006) as compared to the control group. Conclusion: The individual education program on cancer patients who were treated by chemotherapy could be utilized as an effective nursing intervention.