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Development of a $^{68}Ga$-Fluorinated Porphyrin Complex as a Possible PET Imaging Agent
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  • Development of a $^{68}Ga$-Fluorinated Porphyrin Complex as a Possible PET Imaging Agent
  • Development of a $^{68}Ga$-Fluorinated Porphyrin Complex as a Possible PET Imaging Agent
저자명
Fazaeli. Yousef,Jalilian. Amir R.,Amini. Mostafa M.,Ardaneh. Khosro,Rahiminejad. Ali,Bolourinovin. Fatemeh,Moradkhani. Sedigheh,
간행물명
Nuclear medicine and molecular imaging : NMMI
권/호정보
2012년|46권 1호|pp.20-26 (7 pages)
발행정보
대한핵의학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Aim Due to the interesting pharmacologic properties of porphyrins, the idea of developing a possible tumor imaging agent using PET by incorporating $^{68}Ga$ into a suitable porphyrin ligand was investigated. Methods $^{68}Ga$-labeled 5,10,15,20-tetrakis(pentafluoro-13 phenyl) porphyrin ($^{68}Ga$-TFPP) was prepared using freshly eluted $[^{68}Ga]GaCl_3$ obtained from a 68Ge/68Ga generator developed in-house and 5,10,15,20-tetrakis(pentafluorophenyl) porphyrin (H2TFPP) for 60 min at $100^{circ}C$. Results The complex was prepared with high radiochemical purity (>99% ITLC, >99% HPLC, specific activity: 13-14 GBq/mmol). Stability of the complex was checked in the final formulation and in human serum for 5 h. The partition coefficient was calculated for the compound (log P = 0.62). The biodistribution of the labeled compound in vital organs of Swiss mice bearing fibrosarcoma tumors was studied using scarification studies and SPECT imaging up to 1 h. The complex was mostly washed out from the circulation through kidneys and liver. The tumor-to-muscle ratio 1 h post injection was 5.13. Conclusion The radiolabeled porphyrin complex demonstrated potential for further imaging studies in other tumor models.