The muscle strengths in various postures are still used in the workplace, although mechanization and automation have been continuously accomplished. The aim of this study is to measure the maximum muscle strength and analyze the muscle fatigue during the various wrench jobs which are one of the upper limbs related works. Four hundreds and eighty five college students (243 males and 242 females) participated in this study. Twelve muscle strengths which are using for pulling, pushing, lifting and lowering the wrench with various postures are measured. For every moment, the muscle strengths for both hands were measured. In each measurement, five seconds averaged value and peak value were collected. The averaged value of preferred hand and non-preferred hand was compared. Also, the averaged value of opposite movement was compared through t-test. The fatigue of agonist for each movement was analyzed using EMG analysis. The result of this study can provide some basic information not only in designing the tools in work but also in selection, training and management of workers.